GNE

Across TCGA pan-cancer cohorts, GNE mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GNE data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GNE mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GNE expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

LUAD, COAD, and PDAC are the cancer types where GNE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	II,III,IV	0.244	0.878	.001	15	view →
COAD	DFS	Median	III,IV	1.000	0.894	.036	12	view →
PDAC	OS	Tertile	IV	0.490	0.973	.024	10	view →
LSCC	OS	Tertile	All	0.883	1.000	.017	10	view →
CCRCC	DFS	Tertile	IV	0.887	0.213	.024	6	view →
HNSC	OS	Median	II,III,IV	0.953	1.000	.019	5	view →
GBM	DFS	Median	All	0.414	0.222	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GNE–LUAD (OS)

Open the LUAD breakdown →