GNE

Across TCGA patient cohorts, GNE mutation is significantly associated with the RNA expression of many other genes, with 3,691 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNE-associated genes across cancer lineages are RN7SL607P, RPS29P9, and FBP2P1. Each is linked with GNE in more than 1 cancer types. Because this analysis shows association rather than direction, both GNE-to-partner and partner-to-GNE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL607P grouped by GNE-low versus GNE-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNE→partner) and Y-score (partner→GNE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL607P →	+0.149	+4.503	.008	.005	3	2
BRCA	RPS29P9 →	+0.240	+3.782	<.001	.007	3	2
BRCA	FBP2P1 →	+0.077	+4.857	<.001	.004	3	2
LUSC	RNA5SP248 →	+0.345	+4.070	<.001	.004	3	2
LUSC	RPS26P42 →	+0.209	+4.394	.001	.002	3	2
LUSC	AGGF1P4 →	+0.262	+4.993	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,691 associations by consensus.

RN7SL607P by GNE expression — CESC

Explore this box plot interactively →