GNE

Across TCGA patient cohorts, GNE mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNE-associated genes across cancer lineages are eEF2, TFRC, and 4E-BP1_pT37_T46. Each is linked with GNE in more than 1 cancer types. Because this analysis shows association rather than direction, both GNE-to-partner and partner-to-GNE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GNE-low versus GNE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNE→partner) and Y-score (partner→GNE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.356	+2.584	.005	.010	3	2
UCEC	TFRC →	+0.395	+3.169	.038	.018	3	2
UCEC	4E-BP1_pT37_T46 →	-0.362	-2.446	.007	.018	3	2
UCEC	EGFR_pY1068 →	-0.178	-1.925	.049	.005	3	1
UCEC	GATA6 →	-0.113	-1.807	.046	.025	3	1
UCEC	INPP4B →	-0.279	-3.700	.016	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eEF2 by GNE expression — UCEC

Explore this box plot interactively →