GNE

Across TCGA cell cohorts, GNE RNA expression is significantly associated with the go_rna of many other GO terms, with 3,052 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GNE-associated GO terms across cancer lineages are Amino sugar biosynthetic process, Cellular response to starvation, and UDP-N-acetylglucosamine metabolic process. Each is linked with GNE in more than 9 cancer types. Because this analysis shows association rather than direction, both GNE-to-partner and partner-to-GNE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Amino sugar biosynthetic process grouped by GNE-low versus GNE-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNE→partner) and Y-score (partner→GNE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Amino sugar biosynthetic process →	+0.102	+1.325	<.001	.001	3	10
BLOOD_Lymphoma	Cellular response to starvation →	+0.035	+0.845	.001	.001	3	9
URINARY_TRACT	UDP-N-acetylglucosamine metabolic process →	+0.123	+1.981	.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of hippo signaling →	+0.055	+1.496	.009	.005	3	8
BREAST	Retrograde transport, endosome to Golgi →	+0.069	+1.384	<.001	.003	3	8
UPPER_AERODIGESTIVE_TRACT	Response to starvation →	+0.044	+1.292	.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,052 associations by consensus.

Amino sugar biosynthetic process by GNE expression — URINARY_TRACT

Explore this box plot interactively →