GNE

mutation — cross-omics
Cross-omicsMUTATION → RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, GNE mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GNE-associated genes across cancer lineages are ELOA3DP. Each is linked with GNE in more than 1 cancer types. Because this analysis shows association rather than direction, both GNE-to-partner and partner-to-GNE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by GNE-low versus GNE-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNE→partner) and Y-score (partner→GNE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LARGE_INTESTINEELOA3DP →+0.036+4.273<.001.00631
Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

ELOA3DP by GNE expression — LARGE_INTESTINE

Box plot of ELOA3DP in GNE-low vs GNE-high samples in LARGE_INTESTINE.

Explore this box plot interactively →

Exploration