GNE

Across TCGA cell cohorts, GNE mutation is significantly associated with the mutation status of many other genes, with 2,446 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GNE-associated genes across cancer lineages are UBE2J1, GLYATL1, and IQCC. Each is linked with GNE in more than 2 cancer types. Because this analysis shows association rather than direction, both GNE-to-partner and partner-to-GNE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2J1 grouped by GNE-low versus GNE-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNE→partner) and Y-score (partner→GNE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UBE2J1 →	+5.560	+4.736	.003	.003	1	3
LARGE_INTESTINE	GLYATL1 →	+3.744	+4.044	.003	.003	1	3
BLOOD_Leukemia	IQCC →	+3.823	+4.430	.001	.001	1	2
BLOOD_Leukemia	TMPRSS3 →	+4.145	+4.635	.001	.001	1	2
BLOOD_Leukemia	SLC37A1 →	+3.338	+4.083	.003	.003	1	2
BLOOD_Leukemia	ITGB2 →	+2.823	+3.665	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,446 associations by consensus.

UBE2J1 by GNE expression — BLOOD_Leukemia

Explore this box plot interactively →