GNB5

Across TCGA pan-cancer cohorts, GNB5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GNB5 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GNB5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GNB5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where GNB5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	1.000	0.877	.006	55	view →
LSCC	OS	Median	All	0.762	0.947	.001	23	view →
LUAD	DFS	Quartile	II,III,IV	0.308	0.741	.005	14	view →
PDAC	OS	Tertile	III,IV	0.938	0.264	.006	11	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GNB5–CCRCC (DFS)

Open the CCRCC breakdown →