GNB5

Across TCGA patient cohorts, GNB5 protein abundance is significantly associated with the RNA expression of many other genes, with 9,665 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GNB5-associated genes across cancer lineages are HRC, KLHL3, and PTPRN2. Each is linked with GNB5 in more than 3 cancer types. Because this analysis shows association rather than direction, both GNB5-to-partner and partner-to-GNB5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNB5 versus HRC in UCEC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB5→partner) and Y-score (partner→GNB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HRC →	+0.914	+0.353	<.001	<.001	3	4
BRCA	KLHL3 →	+0.735	+0.757	<.001	<.001	3	4
LUAD	PTPRN2 →	+1.310	+0.484	<.001	<.001	3	4
GBM	GPRASP2 →	+0.653	+0.534	<.001	.001	3	4
GBM	BMERB1 →	+0.702	+0.533	<.001	<.001	3	4
UCEC	MS4A8 →	+1.719	+0.295	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,665 associations by consensus.

GNB5 vs HRC — UCEC

Explore this scatter interactively →