GNB5

Across TCGA patient cohorts, GNB5 mutation is significantly associated with the RNA expression of many other genes, with 1,582 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNB5-associated genes across cancer lineages are RNA5SP34, MIR3908, and RNA5SP264. Each is linked with GNB5 in more than 2 cancer types. Because this analysis shows association rather than direction, both GNB5-to-partner and partner-to-GNB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP34 grouped by GNB5-low versus GNB5-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB5→partner) and Y-score (partner→GNB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP34 →	+0.175	+7.471	.009	.008	3	3
COAD	MIR3908 →	+0.264	+5.734	<.001	<.001	3	3
LIHC	RNA5SP264 →	+0.284	+5.878	<.001	.002	3	2
LIHC	VN1R40P →	+0.055	+5.355	<.001	.005	3	2
UCEC	PIGW →	+0.722	+3.818	.001	<.001	3	2
CESC	MIR6127 →	+0.240	+5.252	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,582 associations by consensus.

RNA5SP34 by GNB5 expression — BRCA

Explore this box plot interactively →