GNB5

Across TCGA patient cohorts, GNB5 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNB5-associated genes across cancer lineages are Rad50, ATM, and 14-3-3_beta. Each is linked with GNB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNB5-to-partner and partner-to-GNB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by GNB5-low versus GNB5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB5→partner) and Y-score (partner→GNB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.226	-2.584	.045	.011	3	2
UCEC	ATM →	-0.534	-2.584	.011	.011	3	2
UCEC	14-3-3_beta →	-0.104	-3.143	.026	.018	3	1
UCEC	EGFR →	-0.205	-3.000	.005	.036	3	1
UCEC	ERK2 →	+0.262	+2.584	.003	.011	3	1
UCEC	ACC_pS79 →	+0.396	+2.999	.014	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Rad50 by GNB5 expression — UCEC

Explore this box plot interactively →