GNB5

Across TCGA cell cohorts, GNB5 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GNB5-associated genes across cancer lineages are C6orf118, PXDNL, and COX6A2. Each is linked with GNB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNB5-to-partner and partner-to-GNB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by GNB5-low versus GNB5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB5→partner) and Y-score (partner→GNB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.146	+3.115	<.001	.004	3	1
LARGE_INTESTINE	PXDNL →	+0.100	+2.878	<.001	.009	3	1
LARGE_INTESTINE	COX6A2 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	SCARA5 →	+0.347	+3.362	.002	.007	3	1
LARGE_INTESTINE	OR1F1 →	+0.363	+2.906	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

C6orf118 by GNB5 expression — LARGE_INTESTINE

Explore this box plot interactively →