GNB4

Across TCGA pan-cancer cohorts, GNB4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GNB4 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GNB4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GNB4 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LSCC, COAD, and LUAD are the cancer types where GNB4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.732	0.990	<.001	38	view →
COAD	DFS	Median	II,III,IV	0.872	1.000	.012	24	view →
LUAD	OS	Tertile	III,IV	0.247	0.686	.013	7	view →
CCRCC	DFS	Median	All	0.888	0.979	.028	4	view →
PDAC	OS	Quartile	III,IV	0.977	0.489	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GNB4–LSCC (OS)

Open the LSCC breakdown →