GNB4

Across TCGA patient cohorts, GNB4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNB4-associated genes across cancer lineages are ERK2, MEK1, and Caspase-7-cleavedD198. Each is linked with GNB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNB4-to-partner and partner-to-GNB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by GNB4-low versus GNB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB4→partner) and Y-score (partner→GNB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.235	+3.169	.006	.018	3	2
UCEC	MEK1 →	+0.407	+3.459	.013	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.959	+3.341	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.272	-3.169	.016	.018	3	1
UCEC	Heregulin →	-0.141	-3.459	.011	.005	3	1
UCEC	Shc_pY317 →	-0.216	-2.700	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ERK2 by GNB4 expression — UCEC

Explore this box plot interactively →