GNB4

Across TCGA cell cohorts, GNB4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GNB4-associated genes across cancer lineages are FCN2, NUPR2, and MAGEB3. Each is linked with GNB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNB4-to-partner and partner-to-GNB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by GNB4-low versus GNB4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB4→partner) and Y-score (partner→GNB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FCN2 →	+0.039	+4.415	<.001	.007	3	1
LARGE_INTESTINE	NUPR2 →	+0.376	+4.273	<.001	.006	3	1
LARGE_INTESTINE	MAGEB3 →	+0.055	+4.467	<.001	.004	3	1
LARGE_INTESTINE	F11 →	+0.057	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

FCN2 by GNB4 expression — LARGE_INTESTINE

Explore this box plot interactively →