GNB3

Across TCGA pan-cancer cohorts, GNB3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GNB3 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GNB3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GNB3 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

PDAC, LUAD, and OV are the cancer types where GNB3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.218	0.958	.017	15	view →
LUAD	OS	Median	II,III,IV	0.840	1.000	.017	12	view →
OV	DFS	Median	All	0.665	0.876	.029	8	view →
GBM	OS	Quartile	All	0.755	0.361	.029	5	view →
CCRCC	OS	Quartile	All	0.836	1.000	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GNB3–PDAC (OS)

Open the PDAC breakdown →