GNB3

Across TCGA patient cohorts, GNB3 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,810 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GNB3-associated proteins across cancer lineages are P3H3, P3H4, and PCOLCE. Each is linked with GNB3 in more than 7 cancer types. Because this analysis shows association rather than direction, both GNB3-to-partner and partner-to-GNB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNB3 versus P3H3 in HNSC, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB3→partner) and Y-score (partner→GNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	P3H3 →	+0.690	+0.647	<.001	.001	3	8
HNSC	P3H4 →	+0.636	+0.628	<.001	.002	3	7
OV	PCOLCE →	+0.716	+0.622	<.001	<.001	3	7
GBM	RBM47 →	-0.654	-0.660	<.001	<.001	3	6
HNSC	SARM1 →	+0.510	+0.724	<.001	<.001	3	6
CCRCC	SERPINF1 →	+0.857	+0.378	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,810 associations by consensus.

GNB3 vs P3H3 — HNSC

Explore this scatter interactively →