GNB3

Across TCGA patient cohorts, GNB3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNB3-associated genes across cancer lineages are eIF4E, JNK_pT183_Y185, and JNK2. Each is linked with GNB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNB3-to-partner and partner-to-GNB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GNB3-low versus GNB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB3→partner) and Y-score (partner→GNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.224	+2.584	.022	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.235	-3.321	.002	.010	3	1
UCEC	JNK2 →	+0.250	+3.009	.006	.019	3	1
UCEC	Ku80 →	+0.384	+2.598	<.001	.006	3	1
UCEC	Notch1 →	+0.184	+2.817	.005	.036	3	1
UCEC	P-Cadherin →	-0.154	-3.159	.021	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eIF4E by GNB3 expression — UCEC

Explore this box plot interactively →