GNB3

Across TCGA cell cohorts, GNB3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GNB3-associated genes across cancer lineages are SIGLEC5, SLC22A7, and COX4I2. Each is linked with GNB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNB3-to-partner and partner-to-GNB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC5 grouped by GNB3-low versus GNB3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB3→partner) and Y-score (partner→GNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SIGLEC5 →	+0.019	+5.415	<.001	.004	3	1
SKIN	SLC22A7 →	+0.036	+6.022	<.001	.001	3	1
BLOOD_Leukemia	COX4I2 →	+0.477	+4.276	<.001	.007	3	1
BLOOD_Leukemia	MCHR2 →	+0.034	+4.539	<.001	.007	3	1
BLOOD_Leukemia	WFDC11 →	+0.030	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TSSK1B →	+0.011	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SIGLEC5 by GNB3 expression — SKIN

Explore this box plot interactively →