GNB2

Across TCGA patient cohorts, GNB2 mutation is significantly associated with the RNA expression of many other genes, with 1,405 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNB2-associated genes across cancer lineages are RNA5SP229, RNU6-907P, and RNU6-767P. Each is linked with GNB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNB2-to-partner and partner-to-GNB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP229 grouped by GNB2-low versus GNB2-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB2→partner) and Y-score (partner→GNB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNA5SP229 →	+0.495	+5.618	<.001	<.001	3	2
HNSC	RNU6-907P →	+0.421	+5.241	<.001	.007	3	2
UCEC	RNU6-767P →	+0.273	+2.393	.009	.001	3	2
UCEC	RNA5SP492 →	+0.278	+2.302	<.001	.003	3	2
UCEC	RPS29P22 →	+0.276	+2.382	.003	<.001	3	2
LUAD	TRMT112P1 →	+0.244	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,405 associations by consensus.

RNA5SP229 by GNB2 expression — LIHC

Explore this box plot interactively →