GNB2

Across TCGA cell cohorts, GNB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,097 significant associations in total. CNS shows the largest number of these associations.

The most reproducible GNB2-associated GO terms across cancer lineages are Pre-mRNA catabolic process, Endoplasmic reticulum-plasma membrane tethering, and Regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with GNB2 in more than 11 cancer types. Because this analysis shows association rather than direction, both GNB2-to-partner and partner-to-GNB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-mRNA catabolic process grouped by GNB2-low versus GNB2-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB2→partner) and Y-score (partner→GNB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Pre-mRNA catabolic process →	+0.128	+0.604	<.001	<.001	3	12
BREAST	Endoplasmic reticulum-plasma membrane tethering →	+0.143	+0.687	.001	.004	3	12
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.190	+0.805	<.001	<.001	3	10
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.156	+0.732	.001	<.001	3	10
LUNG_NSCLC_LUAD	Negative regulation of stress granule assembly →	+0.106	+0.629	<.001	<.001	3	10
STOMACH	tRNA 3'-terminal CCA addition →	-0.113	-0.532	.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,097 associations by consensus.

Pre-mRNA catabolic process by GNB2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →