GNB2

Across TCGA cell cohorts, GNB2 mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible GNB2-associated genes across cancer lineages are PRAMEF7, GPR101, and PRAMEF4. Each is linked with GNB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNB2-to-partner and partner-to-GNB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF7 grouped by GNB2-low versus GNB2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB2→partner) and Y-score (partner→GNB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PRAMEF7 →	+0.116	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	GPR101 →	+0.106	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	PRAMEF4 →	+0.186	+5.357	<.001	.003	3	2
URINARY_TRACT	OR9G1 →	+0.022	+4.087	<.001	.009	3	1
URINARY_TRACT	TRIM49B →	+0.027	+5.044	<.001	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	PRAMEF2 →	+0.182	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

PRAMEF7 by GNB2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →