Across TCGA pan-cancer cohorts, GNB1L Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GNB1L data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher GNB1L Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GNB1L expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

LUSC, BLCA, and LIHC are the cancer types where GNB1L Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.161	0.724	.008	15	view →
BLCA	OS	Median	II,III,IV	1.000	0.406	.016	15	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
SKCM	DFS	Median	III,IV	0.058	0.648	.001	6	view →
GBM	OS	Median	All	0.075	0.416	.011	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: GNB1L tumor-vs-normal RNA expression · all GNB1L data types