Across TCGA pan-cancer cohorts, GNB1L mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GNB1L data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GNB1L mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GNB1L expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

CCRCC, HNSC, and GBM are the cancer types where GNB1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.671	0.906	.003	21	view →
HNSC	DFS	Quartile	III,IV	0.697	0.948	.010	14	view →
GBM	OS	Quartile	All	0.964	0.759	.049	1	view →
LUAD	DFS	Tertile	All	0.935	0.844	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: GNB1L tumor-vs-normal RNA expression · all GNB1L data types