Across TCGA patient cohorts, GNB1L mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNB1L-associated genes across cancer lineages are XBP1, mTOR_pS2448, and mTOR. Each is linked with GNB1L in more than 1 cancer types. Because this analysis shows association rather than direction, both GNB1L-to-partner and partner-to-GNB1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB1L→partner) and Y-score (partner→GNB1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XBP1 →	-0.224	-3.156	.001	.018	3	2
UCEC	mTOR_pS2448 →	-0.174	-3.302	.015	.010	3	1
UCEC	mTOR →	-0.186	-2.459	.017	.020	3	1
UCEC	CD49b →	-0.285	-2.980	.038	.036	3	1
UCEC	Chk2 →	-0.325	-2.459	.004	.020	3	1
UCEC	4E-BP1 →	+0.321	+3.029	.014	.018	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

GNB1L survival (RNA) · tumor vs normal (RNA) · all GNB1L data types