GNB1

Across TCGA pan-cancer cohorts, GNB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GNB1 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GNB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GNB1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

UCEC, CCRCC, and LUAD are the cancer types where GNB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.289	1.000	.008	16	view →
CCRCC	OS	Tertile	All	0.759	0.941	.012	14	view →
LUAD	OS	Tertile	III,IV	0.536	0.994	.030	10	view →
LSCC	DFS	Tertile	III,IV	0.469	1.000	.002	6	view →
PDAC	OS	Quartile	III,IV	0.977	0.390	.011	5	view →
HNSC	DFS	Median	III,IV	0.887	0.680	.009	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GNB1–UCEC (DFS)

Open the UCEC breakdown →