GNB1

Across TCGA patient cohorts, GNB1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,215 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GNB1-associated genes across cancer lineages are FCGR3B, CXCR1, and CORO2B. Each is linked with GNB1 in more than 6 cancer types. Because this analysis shows association rather than direction, both GNB1-to-partner and partner-to-GNB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNB1 versus FCGR3B in PDAC, with a Pearson correlation of -0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB1→partner) and Y-score (partner→GNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FCGR3B →	-1.469	-0.509	<.001	<.001	3	7
HNSC	CXCR1 →	-1.321	-0.490	<.001	<.001	3	7
BRCA	CORO2B →	+0.758	+0.303	<.001	<.001	3	6
GBM	NAMPT →	-1.290	-0.522	<.001	<.001	3	6
HNSC	FFAR2 →	-1.011	-0.271	<.001	<.001	3	6
LSCC	FBLN5 →	+1.036	+0.331	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,215 associations by consensus.

GNB1 vs FCGR3B — PDAC

Explore this scatter interactively →