GNB1

Across TCGA patient cohorts, GNB1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNB1-associated genes across cancer lineages are p62 Lck ligand, PCNA, and VHL. Each is linked with GNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNB1-to-partner and partner-to-GNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by GNB1-low versus GNB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNB1→partner) and Y-score (partner→GNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.418	+2.247	<.001	.001	3	2
UCEC	PCNA →	+0.187	+1.847	.018	.008	3	2
UCEC	VHL →	-0.702	-2.000	.004	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.767	+2.827	<.001	.001	3	2
UCEC	4E-BP1 →	+0.214	+2.029	.031	.017	3	2
UCEC	14-3-3_beta →	-0.095	-2.558	.010	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

p62 Lck ligand by GNB1 expression — UCEC

Explore this box plot interactively →