Across TCGA pan-cancer cohorts, GNAT3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GNAT3 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GNAT3 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated GNAT3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and LIHC are the cancer types where GNAT3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.628	.016	30	view →
HNSC	OS	Median	All	0.138	0.710	.001	30	view →
LIHC	OS	Median	All	0.098	0.774	.001	7	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: GNAT3 tumor-vs-normal RNA expression · all GNAT3 data types