GNAT2

Across TCGA pan-cancer cohorts, GNAT2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GNAT2 data layer compared with 8 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GNAT2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GNAT2 expression acts as an unfavorable survival marker.

COAD, SKCM, and ACC are the cancer types where GNAT2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.556	0.870	.020	9	view →
SKCM	DFS	Median	IV	0.040	0.454	.028	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GNAT2–COAD (OS)

Open the COAD breakdown →