GNAT2

Across TCGA patient cohorts, GNAT2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNAT2-associated genes across cancer lineages are ACVRL1, MSH6, and Annexin-1. Each is linked with GNAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNAT2-to-partner and partner-to-GNAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by GNAT2-low versus GNAT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAT2→partner) and Y-score (partner→GNAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.130	-3.308	.024	.009	3	1
UCEC	MSH6 →	-0.393	-2.321	.004	.033	3	1
UCEC	Annexin-1 →	+0.584	+2.189	.008	.034	3	1
UCEC	Shc_pY317 →	-0.128	-1.700	.047	.044	3	1
UCEC	Caspase-8 →	-0.277	-3.432	.009	.005	3	1
UCEC	Di-Ras3 →	-0.178	-2.222	.004	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ACVRL1 by GNAT2 expression — UCEC

Explore this box plot interactively →