GNAS

Across TCGA pan-cancer cohorts, GNAS mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GNAS data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GNAS mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GNAS expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where GNAS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.925	0.645	.002	35	view →
CCRCC	OS	Quartile	II,III,IV	0.475	0.912	.005	23	view →
LUAD	DFS	Median	III,IV	0.230	0.738	.003	14	view →
GBM	OS	Tertile	All	0.637	0.359	.020	5	view →
PDAC	DFS	Median	II,III,IV	0.678	0.856	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GNAS–HNSC (DFS)

Open the HNSC breakdown →