GNAS

Across TCGA patient cohorts, GNAS RNA expression is significantly associated with the protein abundance of many other proteins, with 12,754 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GNAS-associated proteins across cancer lineages are PTK7, CSE1L, and PFN2. Each is linked with GNAS in more than 5 cancer types. Because this analysis shows association rather than direction, both GNAS-to-partner and partner-to-GNAS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNAS versus PTK7 in CCRCC, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAS→partner) and Y-score (partner→GNAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PTK7 →	+0.419	+0.337	.004	.003	3	6
LSCC	CSE1L →	+0.574	+0.773	<.001	<.001	3	6
HNSC	PFN2 →	+0.900	+0.661	<.001	<.001	3	5
LSCC	ADNP →	+0.488	+0.723	<.001	<.001	3	5
GBM	DEF6_S590 →	-0.756	-0.700	<.001	.009	3	5
OV	DENND1A_S592 →	-0.606	-0.482	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,754 associations by consensus.

GNAS vs PTK7 — CCRCC

Explore this scatter interactively →