GNAS

Across TCGA patient cohorts, GNAS protein abundance is significantly associated with the RNA expression of many other genes, with 9,168 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GNAS-associated genes across cancer lineages are CHRDL1, PPIF, and SMAD9. Each is linked with GNAS in more than 3 cancer types. Because this analysis shows association rather than direction, both GNAS-to-partner and partner-to-GNAS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNAS versus CHRDL1 in COAD, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAS→partner) and Y-score (partner→GNAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CHRDL1 →	+1.061	+0.188	.005	.003	3	3
OV	PPIF →	-0.883	-0.328	<.001	<.001	3	3
GBM	SMAD9 →	+0.765	+0.270	<.001	<.001	3	3
GBM	HIF3A →	+0.963	+0.302	.002	.001	3	3
GBM	ADGRB3 →	+1.278	+0.369	<.001	.001	3	3
GBM	CEP55 →	-0.827	-0.286	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,168 associations by consensus.

GNAS vs CHRDL1 — COAD

Explore this scatter interactively →