GNAQ

Across TCGA patient cohorts, GNAQ RNA expression is significantly associated with the protein abundance of many other proteins, with 17,501 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible GNAQ-associated proteins across cancer lineages are RPL21, RABL6, and PHF2. Each is linked with GNAQ in more than 5 cancer types. Because this analysis shows association rather than direction, both GNAQ-to-partner and partner-to-GNAQ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNAQ versus RPL21 in HNSC, with a Pearson correlation of -0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAQ→partner) and Y-score (partner→GNAQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL21 →	-0.247	-0.475	<.001	.006	3	6
BRCA	RABL6 →	+0.305	+0.590	<.001	.004	3	5
OV	PHF2 →	+0.397	+0.626	<.001	.002	3	5
OV	PSMD5 →	+0.294	+0.520	<.001	.002	3	5
LUAD	RPL3 →	-0.395	-0.487	.001	<.001	3	5
BRCA	RPL4 →	-0.330	-0.548	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,501 associations by consensus.

GNAQ vs RPL21 — HNSC

Explore this scatter interactively →