GNAQ

Across TCGA patient cohorts, GNAQ protein abundance is significantly associated with the RNA expression of many other genes, with 9,311 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GNAQ-associated genes across cancer lineages are GNA14, DUSP4, and CIP2A. Each is linked with GNAQ in more than 5 cancer types. Because this analysis shows association rather than direction, both GNAQ-to-partner and partner-to-GNAQ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNAQ versus GNA14 in BRCA, with a Pearson correlation of 0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAQ→partner) and Y-score (partner→GNAQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GNA14 →	+0.953	+0.264	<.001	.004	3	6
BRCA	DUSP4 →	+1.472	+0.354	<.001	<.001	3	4
UCEC	CIP2A →	-0.950	-0.333	.004	.009	3	4
OV	FAM219B →	+0.522	+0.265	<.001	<.001	3	4
BRCA	SECISBP2 →	+0.457	+0.338	<.001	<.001	3	4
BRCA	KLRG2 →	-1.549	-0.447	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,311 associations by consensus.

GNAQ vs GNA14 — BRCA

Explore this scatter interactively →