GNAQ

Across TCGA patient cohorts, GNAQ mutation is significantly associated with the RNA expression of many other genes, with 1,571 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNAQ-associated genes across cancer lineages are PTGES, RAB36, and KCTD17. Each is linked with GNAQ in more than 2 cancer types. Because this analysis shows association rather than direction, both GNAQ-to-partner and partner-to-GNAQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTGES grouped by GNAQ-low versus GNAQ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAQ→partner) and Y-score (partner→GNAQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTGES →	-0.898	-3.071	.001	<.001	3	3
UVM	RAB36 →	-0.438	-1.321	.003	.001	3	2
UVM	KCTD17 →	-0.849	-1.415	.001	.003	3	2
UVM	CTSH →	-0.584	-2.832	.001	<.001	3	2
UVM	CLIP3 →	-1.076	-1.510	<.001	.003	2	3
UVM	KCNIP3 →	-0.637	-1.362	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,571 associations by consensus.

PTGES by GNAQ expression — UCEC

Explore this box plot interactively →