GNAQ

Across TCGA patient cohorts, GNAQ mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNAQ-associated genes across cancer lineages are Akt_pT308, Tuberin, and Caspase-8. Each is linked with GNAQ in more than 2 cancer types. Because this analysis shows association rather than direction, both GNAQ-to-partner and partner-to-GNAQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by GNAQ-low versus GNAQ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAQ→partner) and Y-score (partner→GNAQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.486	+1.502	.035	.030	3	3
UCEC	Tuberin →	+0.255	+1.847	.010	.008	3	2
UCEC	Caspase-8 →	-0.287	-3.392	.001	<.001	3	2
UVM	AMPK_pT172 →	-0.529	-2.584	.009	.015	3	1
UVM	DJ-1 →	-0.232	-2.584	.033	.015	3	1
SKCM	eEF2K →	+0.435	+2.824	.041	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Akt_pT308 by GNAQ expression — UCEC

Explore this box plot interactively →