GNAQ

Across TCGA cell cohorts, GNAQ mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GNAQ-associated genes across cancer lineages are DCD, OR2AJ1, and KRTAP4-1. Each is linked with GNAQ in more than 1 cancer types. Because this analysis shows association rather than direction, both GNAQ-to-partner and partner-to-GNAQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCD grouped by GNAQ-low versus GNAQ-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAQ→partner) and Y-score (partner→GNAQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DCD →	+0.040	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR2AJ1 →	+0.042	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.151	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR6J1 →	+0.006	+5.643	<.001	.002	3	1
BLOOD_Leukemia	MYOD1 →	+0.022	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR4F6 →	+0.028	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

DCD by GNAQ expression — BLOOD_Lymphoma

Explore this box plot interactively →