GNAO1

Across TCGA pan-cancer cohorts, GNAO1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GNAO1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GNAO1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GNAO1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where GNAO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.914	0.560	.002	33	view →
LUAD	DFS	Median	All	0.812	0.407	<.001	21	view →
HNSC	DFS	Tertile	II,III,IV	0.873	0.991	.009	12	view →
UCEC	OS	Tertile	III,IV	0.346	1.000	.015	12	view →
CCRCC	OS	Quartile	III,IV	0.047	0.985	.017	8	view →
LSCC	DFS	Median	II,III,IV	0.570	0.808	.020	7	view →
GBM	DFS	Tertile	All	0.881	0.683	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GNAO1–PDAC (OS)

Open the PDAC breakdown →