GNAO1

Across TCGA patient cohorts, GNAO1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,902 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GNAO1-associated proteins across cancer lineages are DPYSL2, HDGFL3, and PURA. Each is linked with GNAO1 in more than 5 cancer types. Because this analysis shows association rather than direction, both GNAO1-to-partner and partner-to-GNAO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNAO1 versus DPYSL2 in OV, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAO1→partner) and Y-score (partner→GNAO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DPYSL2 →	+0.630	+0.739	.009	.001	3	6
BRCA	HDGFL3 →	+0.637	+0.569	<.001	.001	3	6
BRCA	PURA →	+0.511	+0.754	<.001	<.001	3	6
PDAC	TMOD2 →	+0.503	+0.516	<.001	<.001	3	6
HNSC	PPP1R12B →	+0.629	+0.303	<.001	<.001	3	5
GBM	PYGM →	+0.703	+0.681	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,902 associations by consensus.

GNAO1 vs DPYSL2 — OV

Explore this scatter interactively →