GNAO1

Across TCGA patient cohorts, GNAO1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNAO1-associated genes across cancer lineages are Annexin-1, 14-3-3_beta, and A-Raf_pS299. Each is linked with GNAO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNAO1-to-partner and partner-to-GNAO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by GNAO1-low versus GNAO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAO1→partner) and Y-score (partner→GNAO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.837	+4.247	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.069	-2.088	.035	.016	3	1
UCEC	A-Raf_pS299 →	-0.101	-2.700	.009	.005	3	1
UCEC	ERK2 →	+0.179	+2.584	.004	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.112	-1.502	.040	.027	3	1
UCEC	JNK2 →	+0.244	+2.097	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Annexin-1 by GNAO1 expression — UCEC

Explore this box plot interactively →