GNAO1

Across TCGA cell cohorts, GNAO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,300 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GNAO1-associated GO terms across cancer lineages are Regulation of proteasomal protein catabolic process, Negative regulation of syncytium formation by plasma membrane fusion, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with GNAO1 in more than 12 cancer types. Because this analysis shows association rather than direction, both GNAO1-to-partner and partner-to-GNAO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of proteasomal protein catabolic process grouped by GNAO1-low versus GNAO1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAO1→partner) and Y-score (partner→GNAO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of proteasomal protein catabolic process →	+0.072	+1.425	<.001	<.001	3	13
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.138	+1.364	<.001	<.001	3	11
OESOPHAGUS	Regulation of syncytium formation by plasma membrane fusion →	+0.122	+1.510	.001	<.001	3	11
BLOOD_Leukemia	Regulation of ubiquitin-dependent protein catabolic process →	+0.035	+0.788	<.001	.002	3	11
OESOPHAGUS	Regulation of post-translational protein modification →	+0.055	+1.288	<.001	<.001	3	10
OESOPHAGUS	Regulation of myoblast fusion →	+0.127	+1.634	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,300 associations by consensus.

Regulation of proteasomal protein catabolic process by GNAO1 expression — OESOPHAGUS

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