GNAO1

Across TCGA cell cohorts, GNAO1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible GNAO1-associated genes across cancer lineages are GSTA5, CLEC2A, and OR11G2. Each is linked with GNAO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNAO1-to-partner and partner-to-GNAO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSTA5 grouped by GNAO1-low versus GNAO1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAO1→partner) and Y-score (partner→GNAO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GSTA5 →	+0.025	+4.794	.001	.001	3	2
LUNG_SCLC	CLEC2A →	+0.129	+5.029	<.001	.006	3	1
LUNG_SCLC	OR11G2 →	+0.030	+5.643	<.001	.002	3	1
STOMACH	AVP →	+0.045	+4.794	<.001	.001	3	1
STOMACH	CLEC10A →	+0.047	+4.129	.001	.007	3	1
STOMACH	MBD3L1 →	+0.030	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GSTA5 by GNAO1 expression — STOMACH

Explore this box plot interactively →