GNAI3

Across TCGA pan-cancer cohorts, GNAI3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GNAI3 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GNAI3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GNAI3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

PDAC, LSCC, and UCEC are the cancer types where GNAI3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.666	0.834	.002	30	view →
LSCC	DFS	Median	III,IV	1.000	0.630	.005	13	view →
UCEC	DFS	Median	All	0.779	0.948	.009	8	view →
LUAD	OS	Tertile	II,III,IV	0.272	0.810	.004	6	view →
CCRCC	OS	Tertile	III,IV	0.964	0.663	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GNAI3–PDAC (DFS)

Open the PDAC breakdown →