GNAI3

Across TCGA patient cohorts, GNAI3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNAI3-associated genes across cancer lineages are Notch1, S6, and IGFBP2. Each is linked with GNAI3 in more than 2 cancer types. Because this analysis shows association rather than direction, both GNAI3-to-partner and partner-to-GNAI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by GNAI3-low versus GNAI3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAI3→partner) and Y-score (partner→GNAI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.169	+3.009	.007	.019	3	3
STAD	S6 →	+0.533	+2.849	.017	.034	3	1
UCEC	IGFBP2 →	-0.666	-2.000	.022	.032	3	1
UCEC	MEK1 →	+0.360	+2.000	.029	.032	3	1
UCEC	p21 →	+0.178	+2.820	.040	.035	3	1
UCEC	JNK2 →	+0.211	+3.331	.018	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by GNAI3 expression — UCEC

Explore this box plot interactively →