GNAI3

Across TCGA cell cohorts, GNAI3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,489 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GNAI3-associated GO terms across cancer lineages are Telomeric 3' overhang formation, Positive regulation of mitotic cell cycle, and Mitotic spindle assembly checkpoint signaling. Each is linked with GNAI3 in more than 15 cancer types. Because this analysis shows association rather than direction, both GNAI3-to-partner and partner-to-GNAI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomeric 3' overhang formation grouped by GNAI3-low versus GNAI3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAI3→partner) and Y-score (partner→GNAI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Telomeric 3' overhang formation →	+0.160	+0.619	<.001	.003	1	16
BREAST	Positive regulation of mitotic cell cycle →	+0.075	+0.683	.008	.003	3	14
CNS	Mitotic spindle assembly checkpoint signaling →	+0.092	+0.455	<.001	<.001	3	14
CNS	Spindle assembly checkpoint signaling →	+0.092	+0.455	<.001	<.001	3	14
CNS	Mitotic spindle checkpoint signaling →	+0.092	+0.455	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Zinc ion import into Golgi lumen →	+0.095	+0.540	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,489 associations by consensus.

Telomeric 3' overhang formation by GNAI3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →