GNA15

Across TCGA patient cohorts, GNA15 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNA15-associated genes across cancer lineages are Notch1, Tuberin, and ATM. Each is linked with GNA15 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNA15-to-partner and partner-to-GNA15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by GNA15-low versus GNA15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNA15→partner) and Y-score (partner→GNA15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.231	+2.820	.001	.035	3	2
UCEC	Tuberin →	+0.405	+2.321	.002	.035	3	2
UCEC	ATM →	-0.650	-3.459	.004	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.877	+2.827	.003	.035	3	2
UCEC	eEF2 →	+0.356	+2.321	.047	.035	3	1
UCEC	EGFR_pY1068 →	-0.287	-3.459	.023	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Notch1 by GNA15 expression — UCEC

Explore this box plot interactively →