GNA15

Across TCGA cell cohorts, GNA15 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,952 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible GNA15-associated GO terms across cancer lineages are Negative regulation of canonical NF-kappaB signal transduction, Positive regulation of response to cytokine stimulus, and Cellular response to estradiol stimulus. Each is linked with GNA15 in more than 10 cancer types. Because this analysis shows association rather than direction, both GNA15-to-partner and partner-to-GNA15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of canonical NF-kappaB signal transduction grouped by GNA15-low versus GNA15-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNA15→partner) and Y-score (partner→GNA15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of canonical NF-kappaB signal transduction →	+0.047	+2.905	.006	<.001	3	11
OESOPHAGUS	Positive regulation of response to cytokine stimulus →	+0.115	+1.880	<.001	.007	3	10
STOMACH	Cellular response to estradiol stimulus →	+0.096	+1.530	.001	<.001	3	10
BREAST	Bone resorption →	+0.069	+1.386	.006	.007	3	10
SKIN	Positive regulation of iron ion transport →	+1.280	+1.614	<.001	.003	3	10
SKIN	Positive regulation of iron ion transmembrane transport →	+1.280	+1.614	<.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,952 associations by consensus.

Negative regulation of canonical NF-kappaB signal transduction by GNA15 expression — LUNG_NSCLC_LUSC

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