GNA14

Across TCGA pan-cancer cohorts, GNA14 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of GNA14’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where GNA14 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types GNA14 is over-expressed in tumor, although a few such as LSCC and CCRCC show the opposite, repressed pattern.

LSCC, CCRCC, and COAD are the cancer types where GNA14 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GNA14 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	−1.036	<.001	8	view →
CCRCC	Male	II,III,IV	−0.766	<.001	8	view →
COAD	Male	III,IV	−0.890	.020	1	view →
LUAD	Female	II,III,IV	+0.350	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

GNA14–LSCC

Open the LSCC breakdown →