GNA13

Across TCGA patient cohorts, GNA13 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNA13-associated genes across cancer lineages are VHL, EGFR, and ETS-1. Each is linked with GNA13 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNA13-to-partner and partner-to-GNA13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by GNA13-low versus GNA13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNA13→partner) and Y-score (partner→GNA13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.904	-1.807	<.001	.025	3	2
UCEC	EGFR →	-0.223	-3.584	<.001	.002	3	1
UCEC	ETS-1 →	-0.258	-1.584	.039	.036	3	1
UCEC	FoxM1 →	+0.243	+3.331	.017	.005	3	1
UCEC	JNK2 →	+0.240	+2.196	.002	.032	3	1
UCEC	Ku80 →	+0.209	+1.887	.024	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

VHL by GNA13 expression — UCEC

Explore this box plot interactively →